Lady Macbeth's plan to reach the throne includes the manipulation of her husband. She is well aware that he loves her, respects her opinion, and wastes no time using this information. The fact that she would manipulate her husband this way is a tragedy because Macbeth cannot see what she is doing to him. She attacks when he conveys a sense of uneasiness in regard to killing Duncan. She states:

Art thou afeard

To be the same in thine own act and valour

As thou art in desire? Wouldst though have that

Which thou esteem'st the ornament of life.

And live a coward in thine own esteem. (I.vii.39-43)

This is a clear example of how she will do whatever she needs to do to reach the throne even if it means belittling her husband. She knows that he wants to be perceived as a strong man rather than a weakling...
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